We supply high quality Mirabegron (CAS 223673-61-8), in stock, factory directly supply to clients, lower prices, more competitiveness.
What is the Mirabegron ?
Mirabegron is Light yellow to yellow solid, while it's Molecular Formula is C21H24N4O2S. Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.
What is the CAS number for Mirabegron ?
The CAS number of Mirabegron is 223673-61-8.
More information of Mirabegron 223673-61-8 are:
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Synonyms
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4-Thiazoleacetamide, 2-amino-N-(4-(2-(((2R)-2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)-;2-Amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide;Betanis;YM 178; |
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CAS Number
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223673-61-8 |
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Molecular Formula
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C21H24N4O2S |
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Molecular Weight
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396.513 |
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Density
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1.314 g/cm3 |
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Melting Point
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138-140 °C |
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Boiling Point
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690.008 °C at 760 mmHg |
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Flash Point
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371.104 °C |
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PSA
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128.51000 |
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LogP
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3.81730 |
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Pka
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13.51±0.70(Predicted) |
What is Mirabegron (223673-61-8) used for?
Betanis (Mirabegron) was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting aniline is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.
InChI:InChI=1/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)
Articles related to Mirabegron:
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Article
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Source
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Preparation method of mirabegron key intermediate
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Paragraph 0049-0051, (2022/01/12)
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Mirabegron impurity compound, and preparation method and application thereof
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Paragraph 0143-0145, (2020/09/23)
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How to get the best price on Mirabegron?
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